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Xenical Information
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Additional Xenical Weight Loss Information
Xenical represents one of the safest weight loss medications. Xenical has been extensively tested throughout Europe, as well as, in the United States. Distinct from other medicines that stimulate the brain to suppress the appetite, Xenical uses a fat blocking mode of action that works non-systematically in the gastrointestinal tract. The end result is approximately 33 percent of dietary fat passes through the body undigested. Therefore, Xenical blocks some 33% of the calories from fat from being absorbed. This allows you to consume less calories and lose weight.
Why is Xenical sometimes referred to as orlistat? Orlistat is the generic name for Xenical. The generic name represents the medications nonproprietary or chemical name, whereas, the brand name is the name a pharmaceutical give to a medication for marketing purposes. How does Xenical work? Distinct from other medications that effect neurotransmitters to stimulate the brain to suppress your appetite. Xenical uses a fat blocking mode of action that works non-systemically in the gastrointestinal tract. Dietary fats are large molecules that must be broken down by enzymes, called lipases, before they can be absorbed into the bloodstream. Xenical interferes with these lipases by forming covalent bonds with the them in the stomach and small intestine, this essentially inactivates the enzymes so they are no longer available to hydrolyze dietary fat into an absorbable state. Thus, allowing for some 33 percent of dietary fats to pass through the gastrointestinal tract unchanged. *Xenical works here, covalently bonding to the pancreatic lipases Xenical was evaluated in a placebo-controlled (sugar pill), double blind study to examine the effectiveness of a medication for weight loss and the prevention of weight regain over a two-year period. During the first year, participants who met the definition of overweight were placed on a low calorie diet while randomly given a placebo or Xenical. Research following the first year indicated those individuals treated with Xenical (120 mg per dose) lost approximately three times more weight than the control (placebo) group. In the second year, participants were placed on a weight maintenance diet and the Xenical group was randomized to receive either a placebo or different doses of Xenical. Results following the second year indicated the individuals on orlistat, 120 mg per dose, three times per day were two times as likely to keep the weight off as those individuals in the control (placebo) group. "This study demonstrates that partial inhibition of fat absorption in obese subjects can produce sustained weight loss," the authors conclude. "Subjects treated with Xenical plus a mildly controlled-energy diet lost significantly more weight than those treated with placebo plus diet even though all subjects received a high standard of care and similar dietary counseling…These observations collectively suggest that Xenical may be a useful adjunct to dietary intervention in producing and maintaining weight loss over two years." Journal of the Medical Association (JAMA. 1999;281:235-242)
Recent study in Switzerland revealed the
following: The 12 month study of 430 overweight men and women
was designed to assess the effectiveness of Xenical in patients who are
responsive to treatment. Patients who achieved 9 per cent (approximately
8kg) weight loss after 3 months and maintained this after a further 3
months of Xenical treatment, were followed for one year.
Commenting on the results, lead study investigator Professor Hermann Toplak from the Karl-Franzens-Universitat, Graz, Austria said, "These results demonstrate the significant benefits of rapid and continuous weight loss with Xenical in a clinical practice setting. Patients who respond rapidly to treatment continue with treatment and achieve long-term weight loss success." Are there any other benefits to taking Xenical other than weight reduction? Yes, studies have shown that even a modest weight loss as a result of Xenical and diet can significantly reduce the following life-risk factors:
What is the appropriate dose of Xenical? The recommended dose of Xenical is one 120-mg capsule taken with each meal that contains fat. Individuals may take Xenical in combination with a moderately reduced calorie diet up to three times per day. In the event, a meal is without fat content or a meal is periodically missed an individual may omit that dose. Doses in excess of 120 mg three times per day have not proven to advantageous to weight reduction. For the best results, individuals should practice eating a well-balanced, moderately reduced calorie diet that contains no more than 30 percent of the calories from fat. What about missed doses of Xenical? If you forget to take your Xenical, you should take the Xenical immediately when you remember, provided no longer than an hour has passed since the last meal. Do not double the dose of Xenical or change the prescribed Xenical dose without the recommendation of a doctor. When is it inappropriate to take Xenical? Xenical is contradicted in the following circumstances:
Should Xenical be taken during pregnancy or while breastfeeding? The safety of Xenical has not been established in pregnant women, therefore Xenical should not be used in women who are trying to get pregnant or in women who are pregnant. Women should not take Xenical while breastfeeding their infant because it is not known whether Xenical is excreted in the breast milk. Does Xenical interact with the use of birth control pills? No, there has not been any clinical data to suggest that Xenical would decrease the effectiveness of birth control pills. Is Xenical appropriate for pediatric or geriatric populations? The safety and efficiency of Xenical in the pediatric population have not been established. In addition, clinical studies concerning Xenical did not include a sufficient number of elderly individuals age 65 years and older to determine whether they respond differently from younger individuals. So at this time pediatric and geriatric populations should refrain from using Xenical until more studies are completed. Can I get Xenical over the counter? No, Xenical is a prescription medication and should only be taken when prescribed by a licensed doctor. Regulations do not permit Xenical to be taken without a prescription. However, secondary to the advent of the internet individuals can now order lifestyle medication, such as, Xenical online. Individuals are ask to complete a medical questionnaire which is subsequently reviewed by a physician, once approved your Xenical order will be shipped discreetly and promptly to you. This represent a safe way to order Xenical without the expensive office visits to your local doctor.
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